To find out if taking Carvedilol (tradename Coreg) with standard Antiepileptic drugs will improve the frequency of epileptic seizures.
Why it might work:
Carvedilol has a structure that may help to reduce removal of some anti-epileptic medications from the brain.
Ages between 12 and 70 years, treatment failure of at least 2 anti-epilepsy drugs, localization-related/focal epilepsy or symptomatic generalized epilepsy, and at least 3 seizures/month (complex partial, absence/petit mal, myoclonic jerks, tonic-clonic/grand mal seizures) in the 3-month period prior to enrolling in study. Ineligibility: asthma or other contraindications to beta-blockers. History of non-epileptic seizures.
A Medical history, physical exam and EKG, blood and urine samples will be performed to determine if you qualify for the study during the screening visit. If you are eligible then you will be part of the study for 17 weeks (4 months). You will be asked to keep a diary of your seizures. There are 5-6 office visits and 3 telephone or email interviews to discuss your diary and dispense study medication.